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Fertility

National Infertility Awareness Week

Every year, during the last week of April, National Infertility Awareness Week is celebrated. This initiative reminds us that infertility knows no cultures, social classes, or borders: it affects women and men of all ages and backgrounds. You might know someone close who is going through this. While supporting a friend or family member in this situation can be challenging, there are simple and effective strategies to provide help empathetically and safely. What is National Infertility Awareness Week and why does it matter? National Infertility Awareness Week (NIAW) brings together healthcare professionals, patients, and advocates to spread information about a problem affecting 1 in 6 people of reproductive age worldwide. During these days, discussions cover prevention, early diagnosis, and treatment options, from lifestyle changes to assisted reproductive technologies (ART). What factors contribute to infertility? Infertility can have many causes. In women, ovulatory disorders, tubal damage, or endometriosis are common. In men, low sperm count, reduced motility, or abnormal morphology often play a key role. Additionally, habits such as smoking, having a BMI over 30 kg/m², excessive alcohol consumption, and stress also affect fertility in both sexes. How do assisted reproductive technologies improve conception rates? At Ingenes we combine advanced ART techniques with personalized care. We offer in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and preimplantation genetic testing (PGT). Each plan is tailored to the patient’s medical profile, optimizing success chances and reducing risks. What lifestyle changes can boost fertility naturally? Some simple adjustments make a difference. Follow a balanced diet rich in antioxidants, maintain a healthy weight (BMI between 18.5 and 24.9), engage in moderate exercise, and limit caffeine to under 200 mg daily (about two 240 ml cups of coffee). Avoid tobacco, moderate alcohol, and devote time to stress-management techniques like yoga or meditation. Why is early medical advice important? Early evaluation by a reproductive specialist allows identification of treatable causes of infertility and initiation of interventions before age becomes a limiting factor. Do not self-medicate without consulting a professional. Visiting an Assisted Reproduction specialist is key to maximizing your chances of pregnancy. At Ingenes we also offer resources and ongoing training so our patients have the information and support they need. Discover other initiatives like International Men’s Health Week: Let’s Talk About Fertility and global campaigns like World Fertility Day. How can you support someone facing infertility? Listen without judgment, offer practical help, and encourage participation in social activities. Learn about the emotional and physical impact of infertility and suggest professional support, whether through therapy, support groups, or patient networks, so no one faces this journey alone. Resources available during National Infertility Awareness Week Webinars, workshops, and social media campaigns offer up-to-date advice on prevention and treatment. Many clinics, including Ingenes, host expert Q&A sessions. Check reliable sources like WHO Infertility and national infertility associations for local events. Frequently Asked Questions 1. Does age affect fertility in women and men? Yes. In women, fertility usually declines after age 35 due to lower ovarian reserve and egg quality. In men, fertility gradually decreases from 40, affecting motility and morphology. Early evaluation helps plan timely interventions. Tests like anti-Müllerian hormone (AMH) and antral follicle count (AFC) assess ovarian reserve; semen analysis measures concentration (million/mL), motility (%), and morphology (% normal forms). 2. What is the success rate of IVF treatments? It depends on age, diagnosis, and clinic protocol. On average, women under 35 achieve live birth rates of 45–55% per cycle; in women over 40, rates drop to 15–20%. Factors like egg quality and embryo grading also influence outcomes. Technologies such as time-lapse and PGT help select viable embryos, improving results. Talk to your specialist for your personalized prognosis. 3. Are there non-medical methods to increase fertility? Lifestyle changes can support reproductive health: Mediterranean diet, healthy weight, less caffeine, quitting smoking, and stress management with mindfulness. Supplements like folic acid (400 µg/day) and vitamin D (600–800 IU/day) are helpful, but always avoid self-medication without consulting a doctor. 4. When should a couple seek medical advice? If they are under 35, after 12 months of unprotected intercourse without pregnancy; if over 35, after six months. Additionally, it’s advisable to seek help earlier if there are irregular cycles, severe endometriosis, or a history of pelvic infections. Early intervention detects issues like polycystic ovary syndrome (PCOS) or male factors, improving prospects by starting appropriate treatment. Sources Consulted World Health Organization. (2023). Infertility. Retrieved from https://www.who.int/health-topics/infertility Practice Committee of the American Society for Reproductive Medicine. (2020). Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertility and Sterility, 113(1), 19–25. https://doi.org/10.1016/j.fertnstert.2019.06.005 Centers for Disease Control and Prevention. (2022). Assisted Reproductive Technology (ART). Retrieved from https://www.cdc.gov/art MedlinePlus. (2023). Fertility. Retrieved from https://medlineplus.gov/fertility.html We know this journey can be difficult, but you are not alone. Seek the support of those who understand you and remember that an assisted reproduction specialist can offer the guidance and support you need to increase your chances of becoming a parent.

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22 de April, 2025 No Comments
Assisted Reproduction

Egg and embryo vitrification

Vitrification is a much more effective procedure than slow freezing, which is the cryopreservation technique that was commonly used before vitrification was invented. However, the eggs and embryos’ survival rate depends on their specific resistance to the freezing procedure, the experience of the specialist who performs it, as well as the technology used. Ingenes specialist team is constantly trained by the world’s most experienced scientists in this area to ensure the best success rates regarding egg and embryo vitrification. When eggs and embryos are vitrified they are cooled about 600 times faster than with conventional freezing. In a single instant, the eggs and embryos go from room temperature to that of liquid nitrogen, which is -196°C. The vitrification technique is useful in the following cases: Vitrification is a much more effective procedure than slow freezing, which is the cryopreservation technique that was commonly used before vitrification was invented. However, the eggs and embryos’ survival rate depends on their specific resistance to the freezing procedure, the experience of the specialist who performs it, as well as the technology used. Ingenes specialist team is constantly trained by the world’s most experienced scientists in this area to ensure the best success rates so you and your partner can achieve your dream of being parents in the least number of attempts. How is vitrification performed? Egg freezing is a much more delicate procedure than freezing semen or embryos. Unlike sperm cells, which are much smaller in size and contain very little water, human eggs are relatively large cells with a lot of water inside them. As a result, they are highly susceptible to forming ice crystals during a conventional freezing procedure. Such ice crystals act as microscopic blades, which damage cell membranes, causing permanent damage and deterioration of the cell. However, in a vitrification procedure cells freeze so quickly that water molecules do not have time to form these crystals. Unlike slow freezing methods, which take up to two hours to take the eggs to a proper freezing temperature, egg vitrification takes only a few minutes. To be able to perform egg vitrification, a patient must undergo an ovarian stimulation cycle to achieve the production of several mature eggs. These are then extracted in a procedure called egg retrieval, which is extremely simple if performed by experienced personnel using adequate technology. Once retrieved, all viable eggs are selected, a cryoprotectant solution is added to them, and they are placed in special straws and submerged in liquid nitrogen. The straws with the patient’s vitrified eggs are duly marked and identified and are stored in specialized tanks, where they can be kept for years until the woman is ready to have children. The devitrification (thawing) procedure is very simple and safe. The eggs must be heated rapidly to reach body temperature and separated immediately from the cryoprotectant. Once thawed, they normally retain the same viability as the moment on which they were frozen, and can be fertilized by Intracytoplasmic Sperm Injection (ICSI), in which a single sperm is injected directly into its cytoplasm. While it is true that in some rare cases, some eggs may be sensitive to freezing and may not survive after thawing, it is important to consider that a much greater percentage of eggs survive and develop adequately after vitrification than after a slow freezing procedure. Egg loss after a conventional freezing and thawing process is between 20 and 30 percent. Meanwhile, more than 95 percent of vitrified eggs survive and develop correctly. In some cases better success rates can be obtained with vitrified eggs than with fresh eggs, as the medication used to induce ovulation at In vitro fertilization (IVF) procedures can sometimes influence the endometrial receptivity, reducing the patient’s embryo implantation rates. This is avoided if the vitrified eggs are used to generate embryos, which are transferred in a posterior ovulatory cycle. As these cells are very sensitive to freezing, the loss of some eggs is sometimes inevitable. Therefore, experts recommend vitrifying at least ten eggs. In comparison, if slow freezing were used, it would be necessary to store between 50 and 100 eggs to achieve the same results, and while the pregnancy rate for slow-frozen eggs is very low, about half of the patients who use vitrified eggs achieve a successful pregnancy. In the case of embryos or fertilized eggs, the traditional preservation process of slow freezing has proven to be effective. However, vitrification always provides better results. Embryos can be vitrified at any developmental stage, from before the first cell division takes place (zygote) to the blastocyst stage, which usually occurs 5 to 6 days after fertilization. Vitrification is a much more effective procedure than slow freezing. However, the eggs and embryos’ survival rate depends on their specific resistance to the freezing procedure, the experience of the specialist who performs it, as well as the technology used. Ingenes specialist team is constantly trained by the world’s most experienced scientists in this area to ensure the best success rates so you and your partner can achieve your dream of being parents in the least number of attempts.

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4 de July, 2024 No Comments
Fertility

Celebrating family pride and diversity in June

The month of June is a special time around the world, as LGBTTTIQ+ Pride Month is celebrated. It is a time to recognize and honor diversity, equality, and inclusion in all its forms. At Ingenes, we join this celebration, highlighting our commitment to all families and offering specialized support for those same-sex couples who want to start a family. The importance of inclusion in Assisted Reproduction At Ingenes, we understand that each family is unique and that love knows no barriers. Our goal is to provide all couples, regardless of sexual orientation, with the tools and support necessary to fulfill their dream of becoming parents.Female couples, in particular, find Ingenes a safe and respectful place where they can receive personalized fertility treatments tailored to their specific needs. Fertility options for female couples Female couples who want to become mothers have several options available at Ingenes. One of the most popular is the ROPA (Couple Egg Reception) method, which allows both women to actively participate in the pregnancy process. This method involves one of the women donating her eggs, which are fertilized with sperm from a donor, and then transferred to her partner’s uterus. In this way, both women have a biological and emotional bond with their sons. In addition to the ROPA method, we also offer artificial insemination with donor sperm and in vitro fertilization (IVF), among other treatments. Our fertility specialists work closely with each couple to determine the best approach, ensuring the process is as comfortable and successful as possible. Celebrating pride at Ingenes Pride Month is a time to celebrate love in all its forms and recognize the struggles and achievements of the LGBTTTIQ+ community. At Ingenes, we are proud to support same-sex couples on their path to motherhood. We strongly believe in equality and creating an inclusive and welcoming environment for all families. During June, we carried out various activities and campaigns to highlight our commitment to the LGBTTTIQ+ community. We offer informative talks, support sessions, and personalized consultations for couples of women who want to learn more about their fertility options. We also participate in Pride events to show our support and promote equality and diversity. Testimonials from happy couples Nothing fills us with more pride than seeing our patients fulfill their dream of being mothers. Over the years, we have had the honor of helping many female couples start their families. Their success stories are a testament to the dedication and commitment of our team. For example, Elvira and Tania, a couple who came to Ingenes for support, managed to conceive their child using the ROPA method. “It was an incredible experience,” says Tania. “The Ingenes team made us feel safe and supported at all times. Now we are a happy family thanks to their help.“ At Ingenes, we believe in equality, inclusion, and the right of everyone to start a family. This June, as we celebrate Pride, we reaffirm our commitment to the LGBTTTIQ+ community and continue to offer specialized fertility services and comprehensive support for all couples of women who wish to become mothers. If you and your partner are considering starting a family, we are here to help you every step of the way.

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28 de June, 2024 No Comments
Fertility

Kourtney Kardashian’s challenge to get pregnant

Kourtney Kardashian, known for her participation in the reality show “Keeping Up with the Kardashians,” has been very open about her struggles to have another child. Recently, she shared shocking details about the methods she has tried to achieve this, highlighting the difficulties that many women face in their quest to have a baby. Kourtney, 44, has revealed that she has gone through multiple cycles of in vitro fertilization (IVF), an experience she described as emotionally draining. Despite her efforts, she has so far failed to get pregnant. In addition to conventional fertility treatments, she has turned to less conventional methods, following advice that could supposedly improve her chances of success. These types of suggestions may seem extreme, but they reflect the desperation and deep desire of many women and couples facing similar problems. Kourtney’s story highlights the importance of having access to reliable information and appropriate fertility treatments. At Ingenes, an institute specializing in assisted reproduction, we deeply understands the emotional and physical impact that fertility problems can have on people. Ingenes is dedicated to providing solutions based on scientific evidence and advanced technology, avoiding resorting to methods without scientific support. In Vitro Fertilization (IVF) at Ingenes IVF is one of the most common and effective treatments available at Ingenes. This procedure involves combining eggs and sperm in a laboratory to create embryos and have them transferred to the uterus. Although IVF can be a long and challenging process, it has allowed many people to achieve their dream of having a baby. Unlike the experiences shared by Kourtney Kardashian, at Ingenes the personalization of treatment for each patient is prioritized. Each IVF cycle is adapted to the specific needs of the person or couple, using the most advanced technologies and the best medical practices. This includes thorough and ongoing evaluation to adjust treatment as necessary and increase the chance of success. Facing emotional challenges Kourtney’s journey also highlights the emotional toll that can accompany fertility treatments. Expectations, hope, and sometimes disappointment can be overwhelming. At Ingenes, comprehensive support is provided to patients, not only through medical treatments but also through counseling and emotional support services. Ingenes professionals understand that each patient is different and that emotional support is crucial to face this process. Additionally, Ingenes promotes education and open communication. Ensures patients understand each step of the process and feel empowered to make informed decisions. Transparency and personalized care are fundamental pillars of the service they offer. Alternatives and treatment options While Kourtney Kardashian explored unconventional methods, at Ingenes they focus on science-backed treatments. In addition to IVF, they offer a variety of assisted reproduction options, such as artificial insemination, egg and sperm donation, and advanced genetic diagnostic techniques to increase the chances of success and reduce the risks. Treatments are customized to fit each patient’s unique circumstances. For example, for women with specific reproductive health problems, techniques such as ICSI (intracytoplasmic sperm injection) can be used to improve the chances of fertilization. Vitrification of eggs and embryos is also offered, allowing patients to preserve their fertility for the future. Kourtney Kardashian’s experience underscores the complexity and emotional impact of fertility treatments. At Ingenes, this complexity is recognized and addressed with a comprehensive approach that combines advanced technology, treatment personalization, and emotional support. By choosing science-backed methods and providing compassionate care, Ingenes helps many people achieve their dream of raising a family safely and effectively.

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6 de June, 2024 No Comments
Fertility

The Human Papillomavirus (HPV) and fertility

Human Papillomavirus (HPV) can cause significant complications, but did you know it might influence fertility? Although HPV does not directly prevent a woman from conceiving, cervical lesions or cervical cancer caused by the virus could affect her reproductive capacity. In men, there is evidence that HPV may alter sperm quality, although the data remain limited. What is HPV and how does it affect female fertility? In general, HPV does not prevent conception, but if it causes cervical changes or cervical cancer, fertility can be affected. Procedures such as conization or LEEP remove affected tissue and can alter cervical mucus, making it harder for sperm to pass. Chemotherapy or radiotherapy used for cancer can reduce ovarian reserve. HPV detection is done through Pap smears and viral DNA tests. If abnormalities are found, colposcopy and biopsy guide treatment. Do not self-medicate; always consult your doctor. Can HPV affect male fertility? Some studies show that HPV can adhere to sperm, reduce motility, and increase DNA fragmentation. A 2011 article in Fertility and Sterility found lower progressive motility and higher early embryo loss in HPV-positive samples. If you have a persistent infection, consult a fertility specialist before making any treatment or medication decisions. Assisted reproductive technologies and HPV In vitro fertilization (IVF) is an option for couples with HPV. Although some studies report slightly lower implantation and pregnancy rates, techniques such as sperm washing and embryo culture help reduce viral load. Talk to your embryologist to design a personalized protocol. More information at Vaginal Infections and Their Impact on Female Fertility. HPV vaccination and fertility The HPV vaccine prevents high-risk strains associated with lesions and cervical cancer. There is no evidence it harms ovarian function or fertility; by protecting you from the virus, you also safeguard your reproductive health. Vaccination is recommended up to age 26, and in some cases up to 45. Consult your doctor to choose the best timing. Preventive measures and screening tests Use condoms in every sexual encounter and get your screening tests: Pap smear every 3 years or co-testing (Pap smear plus HPV DNA test) every 5 years between ages 30 and 65. Early detection of HPV-related changes allows for less invasive treatments and better fertility outcomes. Don’t forget booster doses if needed. For more pregnancy and HPV tips, visit HPV and Pregnancy: What You Should Know. Frequently Asked Questions Can HPV Be Eliminated on Its Own and Restore Fertility? Yes. The immune system usually clears low-risk strains within 12–24 months without causing permanent cervical damage. If no lesions appear, fertility remains intact. High-risk strains can cause lesions that require treatment. Early follow-up reduces the risk of invasive procedures. Lifestyle Changes That Support Fertility with HPV A diet rich in antioxidants (vitamins C and E, folate), regular exercise, good rest, and stress-reduction techniques (yoga, meditation) strengthen reproductive health. Avoid smoking and limit alcohol, as they promote HPV persistence and affect fertility. How Long After Treatment Can I Try to Conceive? After conservative treatments (LEEP, cryotherapy), wait 3 to 6 months to allow cervical healing and reduce preterm birth risk. If you undergo aggressive treatments or chemotherapy, your specialist will assess your ovarian reserve and may recommend egg or embryo freezing before starting. Is Assisted Reproduction Safe If I Have HPV? Yes. Clinics use sperm or embryo washing and careful culture protocols to minimize viral load. Ask about success rates and additional steps with your specialist. Sources Centers for Disease Control and Prevention. (2023). HPV and Cancer. https://www.cdc.gov/hpv/ Münger, K., & Howley, P. M. (2002). Human papillomavirus immortalization and transformation functions. Virus Research, 89(2), 213–228. MedlinePlus. (2022). Human Papillomavirus (HPV). https://medlineplus.gov/hpv.html World Health Organization. (2021). Human papillomavirus (HPV) and cervical cancer. https://www.who.int/news-room/fact-sheets/detail/human-papillomavirus-(hpv)-and-cervical-cancer We know this journey can raise questions and mixed emotions. You are not alone: every case is unique and solvable. Reach out to an assisted reproduction specialist for personalized guidance and professional support.

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18 de April, 2024 No Comments
Assisted Reproduction

What is the difference between oocyte and embryo donation?

Creating a family is a journey filled with hopes and dreams for many people. However, sometimes obstacles arise that demand compassionate and effective solutions. In the field of reproductive medicine, two options stand out that offer new opportunities to those struggling to conceive: egg donation and embryo donation. Although both aim to facilitate the path to motherhood and fatherhood, their differences in application and implications are key to making informed decisions that will last a lifetime. What is egg donation and how does it work? Egg donation has become a beacon of hope for many women and couples. This process allows women with infertility, advanced age, risk of genetic diseases, or desire for motherhood without a partner to access healthy eggs. The donor selection includes a thorough review of medical history, karyotype, and infectious disease tests. Once approved, the donor undergoes controlled ovarian stimulation (150–225 IU of FSH per day for 10–12 days) to develop multiple follicles. During the egg retrieval, 8 to 15 oocytes are collected and then fertilized in vitro with the partner’s or donor’s sperm. After fertilization, embryos are cultured and assessed for morphology and genetic testing before being transferred to the recipient’s uterus. The process requires collaboration among reproductive endocrinologists, embryologists, and mental health professionals. Science and technology join forces to offer a solution to fertility issues once deemed insurmountable. Always avoid self-medication and consult a specialist. What is embryo donation and who benefits? Embryo donation occurs when a couple or individual donates their unused embryos from their IVF cycle to another person or couple. These embryos have already reached key developmental stages (blastocyst on day 5, measuring 150–200 µm), which reduces preparation time. Typically, only one hormone cycle with estradiol valerate (2 mg twice daily) and progesterone (400 mg vaginally per day) is needed. For the recipient, embryo donation offers a more economical and faster route to pregnancy. Always consult a reproductive medicine specialist before using these medications. How do genetic connections differ? In egg donation, the baby inherits half of its genetic makeup from the egg donor and the other half from the biological father or sperm donor. With embryo donation, the child has no genetic tie to the intended parents, as both egg and sperm come from the original donors. This influences perceptions of genetic bonds and guidance on when and how to discuss origins with the child. Emotional, legal, and financial considerations Both options involve a complex emotional journey. Feelings of grief over the absence of a biological link or guilt may arise for donors and recipients. Comprehensive psychological support is essential. Legally, contracts must define parental rights, anonymity, and embryo disposition. Regarding costs, egg donation ranges from USD 8,000 to 15,000, while embryo donation generally costs between USD 4,000 and 7,000 per cycle, depending on the clinic and country. On this path to fulfilling your dream of building a family, always seek guidance from fertility specialists. Visit our Egg Donation page and explore our Embryo Donation options. Frequently Asked Questions Can I Choose the Physical Characteristics of the Donor in Egg Donation? Yes. During selection, clinics provide profiles including age, ethnic background, height, weight, eye and hair color, educational level, and medical history. This helps prospective parents feel connected to the donor, though genetics can always surprise. It’s recommended to accompany this choice with psychological counseling to manage expectations and emotions. How Long Does the Embryo Transfer Process Take? Medical preparation usually lasts 4–6 weeks, including ovarian suppression, endometrial development (minimum 7 mm thickness), and hormonal monitoring with blood tests and ultrasounds. The transfer itself takes about 10 minutes under ultrasound guidance. Afterward, you must wait two weeks for the pregnancy test, resting and avoiding strenuous activities to support implantation. What Are the Risks of Egg and Embryo Donation? Ovarian stimulation carries a 1–5% risk of ovarian hyperstimulation syndrome (OHSS), with abdominal pain, bloating, or fluid accumulation. Egg retrieval is invasive and may involve anesthesia-related risks. In embryo transfer, risks are low but can include infection, bleeding, or cramping. The risk of multiple pregnancies is lower with a single embryo transfer, though it increases if two embryos are transferred. How Do I Decide Between Egg and Embryo Donation? It depends on your priorities: genetic connection, budget, time, and emotional comfort. If you prefer a biological link, egg donation may be the best option. If you seek a quicker and more affordable process, embryo donation is ideal. A consultation with a reproductive endocrinologist, genetic counselor, and psychologist will help align medical recommendations with your values and circumstances. Sources American Society for Reproductive Medicine. (2022). Practice Committee Opinion: Oocyte donation. Fertility and Sterility, 117(3), 497–509. https://doi.org/10.1016/j.fertnstert.2021.12.011 Centers for Disease Control and Prevention. (2023). Assisted Reproductive Technology (ART) Data. https://www.cdc.gov/art/index.html MedlinePlus. (2023). Embryo Donation. U.S. National Library of Medicine. https://medlineplus.gov/ency/article/003079.htm Practice Committee of the American Society for Reproductive Medicine. (2020). Recommendations for practices utilizing embryo donation. Fertility and Sterility, 114(6), 1097–1106. https://doi.org/10.1016/j.fertnstert.2020.08.004 Remember that every story is unique, and although the journey may seem challenging, you are not alone. Seek support from experts and surround yourself with professionals who will guide you every step of the way toward parenthood.

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12 de February, 2024 No Comments
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