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Fertility

65% of women who have their tubal ligation reversed can become pregnant

Tubal ligation is typically a permanent contraception, yet many couples seek reversal to achieve pregnancy. About 65% of women conceive after reversal, though this rate depends on several factors. The technique used in the initial ligation is fundamental. Some methods, like clips or rings, are easier to reverse than cauterization or resection. The length and condition of the remaining tubes also influence the outcome. Healthier and longer tubes, ideally over 4 cm, offer better results. Age also plays a role. Women under 35 have greater ovarian reserve and quality, with success rates close to 70%. After age 40, these figures drop to 30% or less as natural fertility declines. What is tubal ligation reversal, and how does it work? It is a microsurgery that reconnects the cut or sealed fallopian tubes, restoring the pathway for eggs and sperm to meet. Surgeons use microscopes and fine instruments to remove scar tissue and join healthy sections. Success depends on having at least 4 cm of tube remaining and minimal damage to the internal epithelium. What factors influence the success rate? Initial ligation method: Clips or rings are more reversible than cauterization or resection. Women’s age: Up to 70% success in women under 35; about 30% over 40. Tubal condition and length: Healthy segments longer than 4 cm offer better results. Overall reproductive health: Balanced hormones, a healthy uterus, and good semen quality all contribute. Time since ligation: Between 5 and 10 years after the original surgery is usually ideal. Alternatives to reversal If you’re not eligible or prefer less invasive options, the assisted reproduction is available. With IVF, doctors extract eggs, fertilize them in the lab, and transfer embryos to the uterus, bypassing the tubes. Egg or embryo donation is possible for low ovarian reserve. When should you consult a specialist? Professional counseling: Specialists assess your anatomy, AMH (Anti-Müllerian hormone for ovarian reserve), and overall reproductive health before recommending next steps. Risks: Infection, hemorrhage, or ectopic pregnancy are possible. Awareness of these risks protects your health. Emotional aspect: This decision can cause stress. Psychological support and support groups are important. Avoid self-medicating. Before any treatment, see a specialist in assisted reproduction. How long do results take? Recovery after surgery takes about 3 months, confirmed by hysterosalpingography, an X-ray to ensure tubes are open. Pregnancy can occur 6 to 18 months later, depending on age and reproductive health. What if the reversal doesn’t work? If pregnancy hasn’t occurred in 12 to 18 months, the IVF is the next option. For women under 35, each IVF cycle has about a 40% success rate, which declines with age. The emotional aspect after reversal It is natural to experience both hope and nervousness throughout this journey. Celebrate your progress and lean on your partner, medical team, and support groups. They are here to help you succeed. Frequently Asked Questions 1. What is the recovery like? Recovery requires 1 to 2 weeks of rest, with mild discomfort and fatigue. Avoid lifting weights and sexual activity for 4 to 6 weeks. A follow-up imaging test confirms the tubes are open before trying to conceive. Remember, you are not alone during recovery. Emotional support from counseling and support groups is as important as physical healing. These resources can help you navigate anxiety and uncertainty. 2. Do age and ovarian reserve affect success? Yes. Women under 35 have higher conception rates. AMH assesses ovarian reserve; higher values are associated with better outcomes. After age 40, egg quality and quantity decline. 3. Risk of ectopic pregnancy? Yes, it varies between 2% and 10%. Residual scarring can make it difficult for the embryo to pass. Early ultrasounds and hCG tests are essential for detection. 4. Contraception after reversal? After attempting pregnancy, use an IUD or hormonal method. Long-acting reversible methods are over 99% effective, and fertility returns quickly after removal. Sources Consulted American Society for Reproductive Medicine. (2020). Tubal Reversal. https://www.asrm.org Practice Committee ASRM. (2015). Role of tubal surgery in the age of ART. Fertility and Sterility, 103(6), e21–e28. MedlinePlus. (2021). Tubal ligation reversal. https://medlineplus.gov/ency/article/007248.htm Diamond MP, et al. (2017). Microsurgical tubal anastomosis. J Minim Invasive Gynecol, 24(4), 725–731. We know how important this journey is for you. You are not alone. A specialist in assisted reproduction can guide and accompany you every step of the way. ”

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News

Egg donation: your womb changes your baby´s genes

A mother carrying a baby in her womb alters its genes, even when the egg comes from another woman. This means her child will be born with traits similar to hers, according to a study by the Valencia Infertility Institute Foundation (IVI). How does the maternal uterus influence the genes of a donated embryo? The uterus is much more than a container: during gestation there is constant dialogue between embryo and endometrium. Endometrial fluid exosomes release maternal RNA that reaches the embryonic nucleus and regulates gene expression, adjusting physical and health traits. Studies such as “The Marvelous Science of Egg Donation: Beyond Genes” explain this in detail. Electron microscope of an exosome about to adhere to the endometrium (IVI). For nine months, the embryo receives blood, nutrients, and oxygen through the umbilical cord. These biochemical signals vary according to the gestational carrier’s genetics, habits, and lifestyle, reinforcing that egg donation is only the starting point. It is the uterus that shapes and “signs” the DNA that will guide the baby’s development. What epigenetic changes can gestation cause in egg donation? During gestation, epigenetic interaction can influence: Eye color and shape Hair texture and tone Facial expressions, such as the smile Predisposition to certain metabolic or autoimmune diseases These modifications do not replace the donated genetics but regulate the activation or silencing of specific genes. To learn more, see “The Revolutionary World of Fertility and Egg Donation”. How does genetic exchange occur between embryo and endometrium? Exosome releasing maternal RNA into the cytoplasm of a blastocyst (IVI). Exosomes, 50–150 nm vesicles, transport maternal RNA to the blastocyst’s cytoplasm and adjust gene transcription. The result is a unique epigenetic profile that combines the donor’s inheritance and the carrier’s influence. Why is egg donation a great opportunity? Rocío, 52, had her two babies via egg donation at Ingenes. The egg donation experience lets you carry and give birth to a child with a unique maternal genetic imprint. Avoid self-medication and always consult a Assisted Reproduction specialist before starting any fertility treatment. Frequently Asked Questions about egg donation and uterine genetics 1. Does the gestational mother contribute DNA if the eggs are from another person? Yes. Although the main genetic load comes from the donor, during gestation the uterus releases exosomes with RNA that modulate the embryo’s gene expression, influencing physical traits and future health. 2. What risks or benefits does this genetic interaction have? Benefits include better embryo adaptation to the uterine environment and higher implantation rates. As for risks, long-term impact is still under study: so far there is no evidence of adverse effects, but specialized prenatal follow-up is recommended. 3. Can it influence the baby’s temperament? Personality arises from genetics and environment. Egg donation and uterine influence affect physical traits and biochemical predispositions, but parenting style and the postnatal environment are key to the child’s character. 4. How to choose the best clinic for egg donation? Choose centers with international accreditations, multidisciplinary teams, and evidence-based protocols. Review their success rates, lab technology, and psychological support offered before and after birth. Sources Vilella F. et al. (2015). Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome. Development, 142(18), 3210–3221. MedlinePlus. (2023). Assisted Reproductive Technology. U.S. National Library of Medicine. Gardiner K. et al. (2020). Epigenetic modifications during pregnancy: maternal-fetal interactions. Journal of Reproductive Immunology, 138, 103-110. Mor & Cardenas. (2018). The immune system in pregnancy: a unique complexity. American Journal of Reproductive Immunology, 79(3), e12847. We are with you on this journey. If you have questions or are considering egg donation, consult an Assisted Reproduction specialist for the best guidance and support.

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