Ovagen:

Regeneración Ovárica

Significantly increase your chances of having a baby using your own eggs by optimizing both ovarian reserve and egg quality.

Through advanced treatments, it is possible to enhance the quantity and viability of eggs, boosting the success rates of assisted reproduction procedures like In Vitro Fertilization (IVF).

These treatments focus on rejuvenating and preserving reproductive capacity, empowering you to take control of your fertility and plan your future with greater confidence.

By improving egg quality, the risk of genetic abnormalities is reduced, ensuring a safer and healthier reproductive process.

What is Ovarian Regeneration?

Ovarian regeneration is an advanced technique used in fertility treatments that aims to improve the quality and quantity of eggs available in women who still have a sufficient ovarian reserve.

This procedure involves administering nutrients, proteins, and growth factors that directly impact the ovarian microenvironment, optimizing its function and response to hormonal stimulation.

This translates to enhanced egg quality and an increased number of viable embryos during assisted reproduction cycles.

The ovarian microenvironment plays a crucial role in follicle development and egg maturation. Over time, or due to medical conditions, this environment can deteriorate, negatively affecting a woman’s reproductive capacity.

Ovarian regeneration seeks to counteract these effects by using growth factors that promote the health and rejuvenation of ovarian tissues.

By improving this environment, egg maturation is facilitated, and the response to hormonal stimulation is enhanced, allowing for a greater number of higher-quality eggs during a treatment cycle.

This procedure is particularly beneficial for women with diminished ovarian reserve or who have faced difficulties producing sufficient high-quality eggs in previous treatments. However, it is essential that the patient still has adequate ovarian mass, meaning her ovaries are of a suitable size, and there is a minimum number of follicles present that can respond to stimulation.

Ovarian regeneration not only increases the number of eggs available but also improves their quality, which is critical for increasing success rates in treatments like IVF (in vitro fertilization).

Higher egg quality reduces the risks of chromosomal abnormalities and increases the likelihood of obtaining healthy, viable embryos that can lead to a successful pregnancy and a healthy baby.

This innovative treatment is a promising option for women seeking to enhance their reproductive capacity and maximize their chances of achieving pregnancy using their own eggs.

Ovarian regeneration is a safe and minimally invasive technique that can complement other assisted reproduction procedures, offering new hope to those who wish to become mothers despite having a limited ovarian reserve

With this approach, it is possible to extend a woman’s reproductive lifespan and provide better outcomes on the path to motherhood.

Who is Ovagen for?

This treatment is ideal for individuals interested in or undergoing fertility treatment and looking to improve their chances of success using their own eggs. It is designed for women and couples who, for various reasons, aim to maximize their chances of conception without resorting to egg donation. Here are the profiles of those who may benefit from this treatment:

People Who Wish to Have a Baby with Their Own Eggs

This treatment is perfect for women who prefer to conceive using their own eggs rather than donor eggs, as it optimizes the quality and quantity of available eggs, improving the success rates of assisted reproduction treatments.

People Seeking Alternatives to Egg Donation

For those who do not wish to opt for egg donation, this ovarian regeneration and stimulation technique enhances the condition of existing eggs, offering a viable and effective alternative to egg donation.

Women Diagnosed with Age-Related Fertility Issues

As women age, the quality and quantity of their eggs decline, affecting their ability to conceive. This treatment is ideal for women facing difficulties getting pregnant due to age, as it seeks to revitalize remaining eggs and improve ovarian response.

People Who Have Canceled IVF Cycles Due to Low Response

Some women have had to cancel their IVF cycles due to a low ovarian response to treatment. This approach is designed to improve the response to stimulation, enabling the collection of more and higher-quality eggs in future cycles.

Women Under 40 with Low Ovarian Response

For younger women who, despite their age, experience a low ovarian response, this treatment helps increase the number of available eggs and improve egg quality, enhancing the chances of success in assisted reproduction treatments.

Women Over 40 Who Still Have Regular Menstrual Cycles

Even women over 40 with regular menstrual cycles can benefit from this treatment, as it optimizes their remaining reproductive capacity. By improving the ovarian environment and egg quality, the chances of achieving pregnancy using their own eggs increase significantly.

This approach provides a valuable opportunity for individuals seeking to maximize their chances of having a baby with their own eggs, even in challenging situations such as advanced age or low ovarian response.

Ingenes Research Publication

1.- Dinorah Hernández-Melchor, Iván Madrazo, América Padilla-Viveros, Felipe Camargo, Esther López-Bayghen. “Personalized regenerative strategies and molecular diagnosis for in vitro fertilization success: a case report”. Oxford Medical Case Reports. Volume 2023. Issue 4. April 2023. Omad037.

Other Issues Affecting Egg Quality

Age is the most significant factor influencing egg quality, as ovarian reserve and egg quality naturally decline over time. However, other reasons may cause even young women to experience a reduction in egg quality. Additional factors include:

Some additional factors that may influence include:

• Genetic issues: Certain inherited conditions may affect egg quality.

•Immune problems: Immune disorders can interfere with reproductive health.
Cancer treatments: Radiation and chemotherapy can reduce ovarian reserve and affect fertility.
Smoking: Smoking has been shown to decrease egg quality and reduce fertility.

•Endometriosis: This condition can damage the ovaries and affect egg quality.

•Obesity: Higher body mass index (BMI) can negatively impact reproductive health.

•Polycystic Ovary Syndrome (PCOS): Women with PCOS often face challenges with egg quality.

•Low ovarian reserve: Reduced ovarian function can make it harder to conceive.

•Poor ovarian response: Difficulty responding to fertility treatments can hinder success.

Although age remains a key factor, it is essential for women facing any of these issues to seek early evaluation and treatment. Understanding and addressing these factors can significantly improve the chances of success in fertility treatments. If you experience any of these conditions, schedule a consultation with our specialists to evaluate your options and develop a personalized plan that helps you overcome reproductive challenges and achieve your dream of becoming a mother.

Results That Back Us Internationally

At Ingenes, we are proud to be pioneers of ovarian regeneration in Latin America, an advanced technique that has enabled hundreds of women to achieve their dream of becoming mothers using their own eggs.

Just in the past year, we have helped over 200 individuals who were struggling to conceive due to low egg quality or quantity.

Ovarian regeneration is an innovative technique that enhances the ovarian microenvironment, promoting better hormonal stimulation response and increasing the chances of success in assisted reproduction treatments like In Vitro Fertilization (IVF).

Thanks to our experience and cutting-edge technology, we have perfected this process, becoming a regional benchmark. The success of this technique allows women who previously needed to resort to egg donation to now attempt conception with their own eggs, offering them a unique and hopeful opportunity.

If you are seeking alternatives to have a baby using your own eggs, ovarian regeneration at Ingenes could be the solution you’re looking for. With a dedicated team of experts and the most advanced technology, we are here to support you every step of the way toward motherhood.

You’ll Be in the Best Hands

Our research team at Ingenes is deeply committed to innovation and education in the field of reproductive sciences. Through our collaboration with leading researchers from Cinvestav-IPN, we have developed cutting-edge technology and advanced tests, such as the Preimplantation Genetic Testing for Monogenic Diseases (PGT-M).

This test identifies specific hereditary diseases in embryos before implantation, increasing the chances of a successful and healthy pregnancy.

Our team’s focus on research and education allows us to remain at the forefront of reproductive advancements and offer more effective and personalized treatments.

By combining our expertise with the research of leading institutions, we continue to improve fertility outcomes, offering new hope to families seeking to conceive.

Thanks to this partnership, we have made significant advances in early detection of genetic abnormalities, providing our patients the opportunity to prevent the transmission of severe hereditary diseases.

Our mission is to continue innovating and developing solutions that improve the reproductive health of our patients, providing them with access to the latest technology and treatments.

Frequently Asked Questions about Ovarian Regeneration

How Does Ovarian Rejuvenation Work?

Ovarian rejuvenation is a treatment that uses growth factors to enhance the ovarian microenvironment and stimulate the production of higher-quality eggs. This procedure helps restore ovarian function, especially in women with low ovarian reserve or poor response to hormonal stimulation, increasing the chances of a successful pregnancy.

What is Ovarian Rejuvenation (A-PRP)?

Ovarian Rejuvenation with A-PRP (Autologous Platelet-Rich Plasma) involves extracting a blood sample from the patient, processing it to obtain platelet-rich plasma, and injecting it into the ovaries. This treatment promotes cellular regeneration and improves egg quality, optimizing the chances of success in fertility treatments.

What are the benefits of PRP Ovarian Rejuvenation?

The benefits of PRP ovarian rejuvenation are substantial. This procedure can boost ovarian function, increase the number of healthy eggs, and enhance the success rates of treatments like the IVF multi cycle program. PRP ovarian rejuvenation also offers a natural approach by using the body’s own growth factors, reducing the need for donor eggs and providing a more personalized path to parenthood.

What Are the Benefits of Ovarian Rejuvenation with PRP?

Ovarian Rejuvenation with PRP improves egg quality and ovarian function, especially in women with low reserve or advanced age. This treatment increases the chances of pregnancy using one’s own eggs, avoids egg donation, and provides an advanced solution for those who have experienced poor responses in assisted reproduction cycles.

How many eggs should I freeze?

The number of eggs you should freeze depends on several factors, including your age and overall fertility health. During your consultation, the fertility specialist will discuss your options.
In general, younger women produce more eggs, and the quality of the eggs is higher.

For women in their 20s or early 30s, freezing around 10-15 eggs is often recommended to increase the chances of future pregnancy. Women over 35 may need to freeze more eggs due to the natural decline in egg quality with age.

What is the best age to freeze your eggs?

Eggs can be frozen indefinitely, meaning they can be stored for years without any significant decline in quality. The process of vitrification, a rapid freezing technique, ensures that the eggs remain viable for extended periods. There is no set expiration date for frozen eggs, and women have successfully used eggs that were frozen for over a decade. When you’re ready to use your eggs, they can be thawed, fertilized, and transferred as part of an in vitro fertilization (IVF) procedure.

Increase your chances of pregnancy while using your own egg cells with Ovagen

In 86% of post-Ovagen cycles, we obtain eggs for IVF, and in 56%, we have embryos ready for transfer.
Combining Ovagen with PGT-A doubles the chances of having chromosomally healthy embryos.
With transferable embryos, there is up to a 42% chance of pregnancy (vs. 9% without Ovagen).

Key References and Research Supporting Our Treatments

1.- Hsu, Chao-Chin et al. “Live Birth in Woman With Premature Ovarian Insufficiency Receiving Ovarian Administration of Platelet-Rich Plasma (PRP) in Combination With Gonadotropin: A Case Report.” Frontiers in endocrinology vol. 11 50. 19 Feb. 2020, doi:10.3389/fendo.2020.00050

2.- Sfakianoudis, Konstantinos et al. “Autologous Platelet-Rich Plasma Treatment Enables Pregnancy for a Woman in Premature Menopause.” Journal of clinical medicine vol. 8,1 1. 20 Dec. 2018, doi:10.3390/jcm8010001

3.- Panda, Soumya R et al. “A Systematic Review Evaluating the Efficacy of Intra-Ovarian Infusion of Autologous Platelet-Rich Plasma in Patients With Poor Ovarian Reserve or Ovarian Insufficiency.” Cureus vol. 12,12 e12037. 12 Dec. 2020, doi:10.7759/cureus.12037

4.- Pantos, Konstantinos et al. “A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment.” Cell transplantation vol. 28,9-10 (2019): 1333-1340. doi:10.1177/0963689719859539

5.-Sfakianoudis, Konstantinos et al. “A Case Series on Platelet-Rich Plasma Revolutionary Management of Poor Responder Patients.” Gynecologic and obstetric investigation vol. 84,1 (2019): 99-106. doi:10.1159/000491697

6.-Sills, E Scott et al. “First data on in vitro fertilization and blastocyst formation after intraovarian injection of calcium gluconate-activated autologous platelet rich plasma.” Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology vol. 34,9 (2018): 756-760. doi:10.1080/09513590.2018.1445219

7.- Petryk, Nataliia, and Mykhailo Petryk. “Ovarian Rejuvenation Through Platelet-Rich Autologous Plasma (PRP)-a Chance to Have a Baby Without Donor Eggs, Improving the Life Quality of Women Suffering from Early Menopause Without Synthetic Hormonal Treatment.” Reproductive sciences (Thousand Oaks, Calif.) vol. 27,11 (2020): 1975-1982. doi:10.1007/s43032-020-00266-8

8.- Sfakianoudis, Konstantinos et al. “Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women.” Journal of clinical medicine vol. 9,6 1809. 10 Jun. 2020, doi:10.3390/jcm9061809

9.- Melo, P et al. “The use of autologous platelet-rich plasma (PRP) versus no intervention in women with low ovarian reserve undergoing fertility treatment: a non-randomized interventional study.” Journal of assisted reproduction and genetics vol. 37,4 (2020): 855-863. doi:10.1007/s10815-020-01710-z

10.-Cakiroglu, Yigit et al. “Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency.” Aging vol. 12,11 (2020): 10211-10222. doi:10.18632/aging.103403

11.- Farimani, Marzie et al. “A report on three live births in women with poor ovarian response following intra-ovarian injection of platelet-rich plasma (PRP).” Molecular biology reports vol. 46,2 (2019): 1611-1616. doi:10.1007/s11033-019-04609-w