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Looking for an alternative to egg donation? Your age is not a barrier!

Ovarian regeneration is a safe and effective option that increases the chances of having a baby with your own eggs.
What is Ovarian Regeneration?
Ovarian regeneration uses nutrients, proteins, and growth factors to enhance the ovarian environment, improve response to stimulation, and increase egg quality. Ovagen is a safe and effective option to consider before egg donation.

Who is Ovagen: Ovarian Rejuvenation ideal for?

Ovarian regeneration uses nutrients, proteins, and growth factors to enhance the ovarian environment, improve response to stimulation, and increase egg quality. Ovagen is a safe and effective option to consider before egg donation.
ingenes_pgt-m_que_es-investigadora-biologia-molecular-adina-newman-realizando-procedimiento-en-laboratorio
• Those wanting to have a baby with their own eggs
• Those looking for alternatives to egg donation
• Women diagnosed with fertility issues due to age but still wish to try conceiving
• Individuals who have cancelled IVF cycles due to poor response
Women under 40 with low ovarian response or diminished ovarian reserve
• Women over 40 who still have menstrual cycles and hope to improve their chances of success through ovarian regeneration
• By addressing these fertility challenges, Ovagen provides an option for women to pursue pregnancy without the need for egg donation, enhancing the opportunity to conceive naturally.

Ingenes Research Publication

1.- Dinorah Hernández-Melchor, Iván Madrazo, América Padilla-Viveros, Felipe Camargo, Esther López-Bayghen. “Personalized regenerative strategies and molecular diagnosis for in vitro fertilization success: a case report”. Oxford Medical Case Reports. Volume 2023. Issue 4. April 2023. Omad037.

Is Ovarian Regeneration Right for You?

Ovarian regeneration might be right for you if you're looking for ways to improve your chances of having a baby with your own eggs. This innovative treatment works by improving ovarian function and enhancing the quality of your eggs. It’s beneficial for women who have struggled with poor response during previous IVF cycles or those seeking alternatives to egg donation.
Schedule a consultation to determine if this treatment suits you and increases your chances of having a baby with your own eggs. We'll assess your ovarian reserve, overall health, and reproductive goals to create a personalized plan tailored to your unique needs.

Schedule Your Appointment

Understanding Your Ovarian Reserve

The ovarian reserve is the number of eggs available in a woman's ovaries. Women are born with about 1 million eggs, which decrease with age.

By the time women reach their most fertile years (20-30), only about 400 eggs remain. This number continues to decline until menopause, affecting both the quantity and quality of eggs.

Other Factors Affecting Egg Quality

Ovarian rejuvenation can improve egg quality, but several factors can still impact fertility, including:

Genetic issues: Certain inherited conditions may affect egg quality.
Immune problems: Immune disorders can interfere with reproductive health.
Cancer treatments: Radiation and chemotherapy can reduce ovarian reserve and affect fertility.
Smoking: Smoking has been shown to decrease egg quality and reduce fertility.
Endometriosis: This condition can damage the ovaries and affect egg quality.
Obesity: Higher body mass index (BMI) can negatively impact reproductive health.
Polycystic Ovary Syndrome (PCOS): Women with PCOS often face challenges with egg quality.
Low ovarian reserve: Reduced ovarian function can make it harder to conceive.
Poor ovarian response: Difficulty responding to fertility treatments can hinder success.
Addressing these factors through ovarian rejuvenation and the multi cycle IVF approach can help overcome some of these challenges.

Internationally Recognized Results

In the last year, Ingenes has helped over 200 individuals achieve pregnancy with their own eggs through ovarian regeneration, making us experts and pioneers in Latin America. Our expertise and dedication to innovation have established us as pioneers in reproductive medicine, providing hope for families who may have otherwise faced limited options.

Ovagen Application Procedure: Step-by-Step

Ovagen, our specialized ovarian rejuvenation treatment, follows a precise application process to maximize its effectiveness. This procedure is designed to boost your ovarian function and improve your chances of success in subsequent IVF cycles. Here’s what you can expect from the Ovagen application:
1. Blood Sample Collection:
The process begins with the collection of a blood sample taken from your arm. This blood sample is essential for processing the growth factors that will be used to enhance ovarian regeneration.
2. Processing Growth Factors:
While your nurse prepares you for the Ovagen application, the blood sample is processed in the lab to obtain Endogenous Growth Factors. These growth factors are the key to stimulating ovarian regeneration.
3. Delivery to Doctor:
Thirty minutes later, these nutrients are delivered to your doctor.
4. Application in the Operating Room:
In the operating room, your doctor applies the nutrients directly to the ovaries. This outpatient procedure takes approximately 20 minutes. This minimally invasive application is critical to initiating the ovarian rejuvenation process.
5. Post-Procedure Recommendation:
After the application, it is recommended to wait 1 to 3 months before starting ovarian stimulation for optimal results. This waiting period allows time for the growth factors to work and optimizes your chances of retrieving high-quality eggs during your multi cycle IVF treatments.

Advancing Reproductive Science with Ovagen

Our research team is dedicated to innovation and teaching in reproductive sciences, developing cutting-edge technology and new methods to increase success rates and achieve pregnancy in the shortest time possible. In collaboration with leading researchers from Cinvestav-IPN, we've developed Ovagen. 

Ovarian rejuvenation is just one example of our cutting-edge approach to fertility care. By offering the latest in ovarian regeneration techniques, we help women increase their chances of achieving pregnancy with their own eggs, reducing the need for egg donation.

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Increase your chances of pregnancy while using your own egg cells with Ovagen

Ovagen has demonstrated significant success in helping women conceive using their own eggs. In 86% of post-Ovagen cycles, we obtain eggs for IVF, and in 56%, we have embryos ready for transfer. Combining Ovagen with preimplantation genetic testing (PGT-A) doubles the chances of having chromosomally healthy embryos.
With transferable embryos, there is up to a 42% chance of pregnancy (vs. 9% without Ovagen).

If you are interested in learning more about how ovarian rejuvenation and IVF can help you achieve your dream of parenthood, contact us today to explore all the options.

Frequently Asked Questions

How Ovarian Rejuvenation Works?

Ovarian rejuvenation is a technique designed to improve ovarian reserve and egg quality. This process involves injecting growth factors into the ovaries to stimulate natural regeneration. Ovarian rejuvenation enhances the ovaries’ ability to produce healthier eggs, which can be used in fertility treatments like the IVF multi cycle program. It's effective for women experiencing low ovarian response or diminished ovarian reserve.

What does Ovarian Rejuvenation (A-PRP) involve?

Ovarian rejuvenation with A-PRP (Autologous Platelet-Rich Plasma) involves the extraction and preparation of a patient’s own blood to isolate growth factors. These growth factors are then injected directly into the ovaries to stimulate ovarian regeneration. The goal of A-PRP is to rejuvenate the ovaries, improving their ability to produce higher-quality eggs. This process can significantly enhance outcomes in multi cycle IVF treatments.

How many eggs should I freeze?

The number of eggs you should freeze depends on several factors, including your age and overall fertility health. During your consultation, the fertility specialist will discuss your options.
In general, younger women produce more eggs, and the quality of the eggs is higher.

For women in their 20s or early 30s, freezing around 10-15 eggs is often recommended to increase the chances of future pregnancy. Women over 35 may need to freeze more eggs due to the natural decline in egg quality with age.

What are the benefits of PRP Ovarian Rejuvenation?

The benefits of PRP ovarian rejuvenation are substantial. This procedure can boost ovarian function, increase the number of healthy eggs, and enhance the success rates of treatments like the IVF multi cycle program. PRP ovarian rejuvenation also offers a natural approach by using the body’s own growth factors, reducing the need for donor eggs and providing a more personalized path to parenthood.

What is the best age to freeze your eggs?

The best age to freeze your eggs is typically in your late 20s to early 30s, when egg quality and quantity are at their peak. During this time, women tend to produce more eggs that are healthier, increasing the chances of a successful pregnancy later on.

Every woman’s fertility is different, and some may choose to freeze their eggs earlier or later depending on personal or medical reasons. Your fertility specialist can help determine the best timing based on your individual circumstances.

Eggs can be frozen indefinitely, meaning they can be stored for years without any significant decline in quality. The process of vitrification, a rapid freezing technique, ensures that the eggs remain viable for extended periods. There is no set expiration date for frozen eggs, and women have successfully used eggs that were frozen for over a decade. When you’re ready to use your eggs, they can be thawed, fertilized, and transferred as part of an in vitro fertilization (IVF) procedure.

Increase your chances of pregnancy while using your own egg cells with Ovagen

• In 86% of post-Ovagen cycles, we obtain eggs for IVF, and in 56%, we have embryos ready for transfer.
• Combining Ovagen with PGT-A doubles the chances of having chromosomally healthy embryos.
• With transferable embryos, there is up to a 42% chance of pregnancy (vs. 9% without Ovagen).

Contact us to explore all the options to make your dream of holding your baby come true.
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Key References and Research Supporting Our Treatments

1.- Hsu, Chao-Chin et al. “Live Birth in Woman With Premature Ovarian Insufficiency Receiving Ovarian Administration of Platelet-Rich Plasma (PRP) in Combination With Gonadotropin: A Case Report.” Frontiers in endocrinology vol. 11 50. 19 Feb. 2020, doi:10.3389/fendo.2020.00050

2.- Sfakianoudis, Konstantinos et al. “Autologous Platelet-Rich Plasma Treatment Enables Pregnancy for a Woman in Premature Menopause.” Journal of clinical medicine vol. 8,1 1. 20 Dec. 2018, doi:10.3390/jcm8010001

3.- Panda, Soumya R et al. “A Systematic Review Evaluating the Efficacy of Intra-Ovarian Infusion of Autologous Platelet-Rich Plasma in Patients With Poor Ovarian Reserve or Ovarian Insufficiency.” Cureus vol. 12,12 e12037. 12 Dec. 2020, doi:10.7759/cureus.12037

4.- Pantos, Konstantinos et al. “A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment.” Cell transplantation vol. 28,9-10 (2019): 1333-1340. doi:10.1177/0963689719859539

5.-Sfakianoudis, Konstantinos et al. “A Case Series on Platelet-Rich Plasma Revolutionary Management of Poor Responder Patients.” Gynecologic and obstetric investigation vol. 84,1 (2019): 99-106. doi:10.1159/000491697

6.-Sills, E Scott et al. “First data on in vitro fertilization and blastocyst formation after intraovarian injection of calcium gluconate-activated autologous platelet rich plasma.” Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology vol. 34,9 (2018): 756-760. doi:10.1080/09513590.2018.1445219

7.- Petryk, Nataliia, and Mykhailo Petryk. “Ovarian Rejuvenation Through Platelet-Rich Autologous Plasma (PRP)-a Chance to Have a Baby Without Donor Eggs, Improving the Life Quality of Women Suffering from Early Menopause Without Synthetic Hormonal Treatment.” Reproductive sciences (Thousand Oaks, Calif.) vol. 27,11 (2020): 1975-1982. doi:10.1007/s43032-020-00266-8

8.- Sfakianoudis, Konstantinos et al. “Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women.” Journal of clinical medicine vol. 9,6 1809. 10 Jun. 2020, doi:10.3390/jcm9061809

9.- Melo, P et al. “The use of autologous platelet-rich plasma (PRP) versus no intervention in women with low ovarian reserve undergoing fertility treatment: a non-randomized interventional study.” Journal of assisted reproduction and genetics vol. 37,4 (2020): 855-863. doi:10.1007/s10815-020-01710-z

10.-Cakiroglu, Yigit et al. “Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency.” Aging vol. 12,11 (2020): 10211-10222. doi:10.18632/aging.103403

11.- Farimani, Marzie et al. “A report on three live births in women with poor ovarian response following intra-ovarian injection of platelet-rich plasma (PRP).” Molecular biology reports vol. 46,2 (2019): 1611-1616. doi:10.1007/s11033-019-04609-w

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