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Endogen:
Endometrial Regeneration

Significantly increase your chances of having a baby by improving the quality of your endometrium, the tissue where the embryo implants. A healthy and receptive endometrium is essential for the embryo to adhere properly and develop into a successful pregnancy.
Treatments aimed at improving endometrial quality optimize uterine conditions, facilitating implantation and reducing the risk of failure during this delicate process.
Additionally, these treatments help balance the uterine environment, promoting an ideal setting for early embryonic development. By enhancing endometrial receptivity, your chances of success increase significantly, giving you greater peace of mind on your journey to motherhood.
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What is the Endometrium?

The endometrium is the inner lining of the uterus, a dynamic tissue that undergoes cyclical changes in response to hormonal signals, preparing for the implantation of a fertilized egg. If fertilization occurs, the blastocyst (early embryo) implants into the endometrial lining, where it receives nutrients from blood vessels to support fetal development. If fertilization does not occur, the endometrium is shed during menstruation, and the cycle begins anew.
However, certain anomalies in the endometrium can affect fertility and hinder implantation. These conditions include:

• Asherman’s Syndrome (uterine scarring)
• Refractory Endometrium (non-responsive to stimulation)
• Thin Endometrium
• Uterine Lesions
• Implantation Failure

These anomalies limit the endometrium’s ability to receive and nourish the embryo, reducing the chances of success in fertility treatments.

Let’s Talk About Endometrial Quality

• Age of the woman
• Hormonal imbalance
• Endometrial inflammation
• Structural anomalies

A low-quality endometrium may be too thin or lack sufficient vascularization to support embryonic growth, significantly reducing the chances of a successful pregnancy.
Un endometrio de baja calidad puede ser demasiado delgado o no tener la suficiente vascularización para permitir el crecimiento del embrión, afectando así las probabilidades de un embarazo exitoso.
Endometrial quality is a crucial factor for implantation and a successful pregnancy. A healthy endometrium is essential for the embryo to adhere and receive the necessary support during the early stages of development. Endometrial quality refers to the tissue’s ability to facilitate implantation and promote proper embryonic growth.

Several factors can affect endometrial quality, including:

What is Endometrial Regeneration?

Endogen is an advanced endometrial regeneration treatment specifically designed to improve uterine conditions and increase the chances of having a baby.

This treatment is safe and effective, making it an ideal option for women who face difficulties with embryo implantation during In Vitro Fertilization (IVF) procedures.

Its primary goal is to prepare the endometrium by creating a suitable environment for the embryo to implant successfully and develop into a healthy pregnancy.

The endometrium, the inner layer of the uterus, plays a critical role in the success of embryo implantation. If this tissue is not in optimal condition, the embryo may struggle to adhere and continue its development.

Endogen works by improving the quality of this tissue, promoting its regeneration, and enhancing its receptivity.

Ingenes resources

1.- Dinorah Hernandez-Melchor, B.SC.; Ginna Milena Ortiz, MD; Ivan Madrazo, M.D.; Norma Indira Barrera Vargas, M.B., M.B.B.S., M.SC.; America Padilla, PhD; Esther Lopez-Bayghen, PhD. “Trans myometrial injection of autologous mesenchymal stem cells improves endometrial quality and art results in patients with refractory endometrium or Asherman's Syndrome”. Fertility and Sterility. ASRM. Volume 118, Issue 4, Supplement , E169, October 2022. 2.- Hernández-Melchor D, Palafox-Gómez C, Madrazo I, Ortiz G, Padilla-Viveros A, López-Bayghen E. “Surgical and nutritional interventions for endometrial receptivity: A case report and review of literature". World Journal of Clinical Cases. November 2022. 3.- Dinorah Hernandez-Melchor, B.Sc.; Hector Jesus Carrillo Vidrio, MD; Martin Rivera, M.D., M.SC.; Leonardo M. Porchia, PhD; America Padilla, PhD; Esther Lopez-Bayghen, PhD. “Pautologous platelet-rich plasma treatment improves embryo implantation and clinical pregnancy rates in women undergoing assisted reproduction: a pilot study and systematic review”. Fertility and Sterility. ASRM. Volume 118, Issue 4, Supplement, E169-E170, October 2022.

Who Is It Recommended For?

Patients diagnosed with Asherman’s Syndrome—a condition characterized by the formation of scar tissue in the uterus—or those with atrophic or refractory endometrium (when the endometrial tissue does not develop properly) may experience difficulties achieving embryo implantation, significantly reducing their chances of success in fertility treatments. These conditions directly impact endometrial quality, impairing its ability to receive and nurture an embryo during assisted reproduction processes.

Asherman’s Syndrome can result from:

  • Uterine infections
  • Previous surgical procedures, such as curettage
  • Postpartum complications

These factors lead to the formation of intrauterine adhesions that disrupt the uterine cavity. These adhesions prevent proper endometrial development, complicating implantation and, consequently, the ability to conceive.

On the other hand, atrophic endometrium is characterized by thinning of the endometrial tissue, making it less receptive and hindering implantation. In many cases, the endometrium does not respond to traditional stimulation treatments, which can be frustrating for patients striving to achieve pregnancy.

In these cases, obtaining an accurate and personalized diagnosis is crucial to assess the severity of the issue and determine the most effective treatment. Advances in reproductive medicine have led to the development of innovative alternatives, such as Endogen and other endometrial regeneration treatments, which can improve endometrial quality and restore its ability to receive an embryo.

Endometrial regeneration treatments offer a promising solution for patients diagnosed with Asherman’s Syndrome or atrophic/refractory endometrium. These treatments are designed to enhance endometrial quality, whether by eliminating scar tissue or promoting endometrial growth through advanced therapies such as Platelet-Rich Plasma (PRP), growth factors, and other regenerative techniques.

These options can significantly increase the chances of success in fertility treatments like In Vitro Fertilization (IVF).

If you suspect you may be facing any of these issues, it is essential to consult a fertility specialist. An accurate diagnosis will help you identify the best available options and improve your chances of achieving the pregnancy you’ve been dreaming of.

At Ingenes, we have the resources and expertise to provide a comprehensive evaluation and offer you a personalized treatment plan tailored to your specific needs.

Is Endometrial Regeneration Right for You?

Schedule your appointment with us and find out if you are a candidate for this innovative endometrial regeneration treatment or any other fertility procedure that could improve your chances of success.
By conducting a personalized evaluation, our Assisted Reproduction specialists will determine the best option for you, considering your medical history, reproductive health, and any prior treatments.

This tailored approach allows us to provide specific solutions to maximize your chances of having a baby.
Este enfoque personalizado nos permite ofrecer soluciones específicas para maximizar tus probabilidades de tener un bebé.

The first step is receiving a detailed diagnosis to determine whether this treatment is right for you.

By undergoing an evaluation with our team, you’ll gain a clear understanding of your reproductive health and learn about the best options available for your unique case.

At Ingenes, we have a team of experts and advanced technology to support you every step of the way, providing the best possible care and significantly increasing your chances of conception.

Don’t wait any longer. Taking action now can make all the difference on your path to motherhood.

Agenda tu cita con nosotros, y comienza a explorar las alternativas que tenemos para ayudarte a cumplir tu sueño de ser mamá.

Endogen: Enhancing Endometrial Quality with Endogenous Growth Factors

Endogenous growth factors are a concentrated mix of proteins and nutrients derived from platelet-rich plasma (PRP). These factors play a crucial role in tissue repair and regeneration by stimulating the development of new healthy cells and promoting the formation of new blood vessels and capillaries. This improved vascularization enhances the functionality of the endometrial tissue, allowing it to respond more effectively to hormonal signals that prepare it for embryo implantation.
The regeneration of the endometrium using endogenous growth factors is an innovative advancement in fertility treatments. It is particularly effective in cases where the endometrial tissue struggles to achieve the thickness and quality needed for successful implantation. This process involves applying growth factors directly to the uterus, improving the endometrium’s receptivity and significantly increasing the chances of success in assisted reproduction treatments, such as In Vitro Fertilization (IVF).
Treatment with endogenous growth factors typically requires 2 to 3 applications to achieve a significant improvement in endometrial quality. Throughout the process, specialists closely monitor tissue development and adjust the treatment based on the endometrium’s response. These applications not only enhance the endometrium’s ability to receive an embryo but also create a healthier and more optimal environment for early pregnancy development.
Enhancing endometrial quality with this treatment has a direct and positive impact on implantation success rates. By increasing tissue thickness, improving vascularization, and fostering a more receptive environment, the chances of successful embryo implantation and development are significantly elevated.
This treatment is particularly beneficial for patients who have experienced implantation failures in previous IVF cycles or have been diagnosed with a thin or low-quality endometrium. The application of endogenous growth factors is a minimally invasive and safe procedure that has proven to be highly effective in improving endometrial receptivity. For those looking to maximize their chances of having a baby through Assisted Reproduction, this treatment is an ideal option.
Consulting with a fertility specialist can help determine whether this approach suits your unique needs and how it can be incorporated into your personalized fertility treatment plan.

In summary, Endogenous growth factors not only regenerate endometrial tissue but also optimize the conditions for embryo implantation and development, offering new hope to those facing challenges on their path to parenthood. By improving the quality and receptivity of the endometrium, this innovative treatment paves the way for increased success rates in Assisted Reproduction.xss

How does it work?

95%

At Ingenes, we successfully improve endometrial quality and thickness in 95% of patients through Endogen.

68.3%

This innovative treatment increases pregnancy probabilities by 68.3%.
Our success rates using endometrial regeneration are among the highest across fertility institutions, centers, and clinics, even surpassing those reported in medical and scientific publications.

You're in the Best Hands!

Endometrial regeneration with stem cells is an innovative and promising therapeutic approach to treat endometrial disorders that impact fertility. This treatment leverages the unique ability of stem cells to regenerate and repair damaged tissue, offering an effective solution for women who have faced challenges in embryo implantation due to endometrial issues. Stem cells have the capacity to differentiate into various cell types and, when applied to the uterus, can help restore the functionality and quality of the endometrium.
For women with conditions such as Asherman’s Syndrome (characterized by uterine scarring) or atrophic endometrium (where the endometrial tissue is thin or of low quality), endometrial regeneration with stem cells has proven to be an effective solution to enhance uterine receptivity. This treatment promotes the regeneration of endometrial tissue, increasing its thickness and responsiveness to hormonal signals that prepare the uterus for embryo implantation. It is particularly valuable for women who have experienced recurrent implantation failures during assisted reproduction treatments like In Vitro Fertilization (IVF).
Stem cell therapy improves the quality of the endometrium by stimulating the development of new blood vessels and fostering a more receptive environment for the embryo. This results in a significant improvement in pregnancy rates for women who previously had limited chances of success due to low-quality endometrial tissue. By enhancing the thickness and vascularization of the endometrium, stem cells provide renewed hope for those struggling to conceive due to uterine issues.
The procedure is minimally invasive and typically involves extracting stem cells from the patient’s own body, reducing the risk of rejection and ensuring greater compatibility. These cells are cultivated and prepared in a laboratory before being injected into the uterus. As the stem cells regenerate the endometrial tissue, the uterus becomes more receptive, significantly increasing the chances of successful embryo implantation and the development of a healthy pregnancy.
In summary, endometrial regeneration with stem cells is a revolutionary therapeutic option that can significantly enhance pregnancy rates in women with endometrial issues. By restoring uterine tissue and improving endometrial receptivity, this treatment offers new hope to those seeking to fulfill their dream of becoming mothers.
En resumen, la regeneración endometrial con células madre es una opción terapéutica revolucionaria que puede mejorar significativamente las tasas de embarazo en mujeres con problemas endometriales. Al restaurar el tejido uterino y mejorar la receptividad del endometrio, este tratamiento ofrece una nueva esperanza para aquellas que buscan cumplir su sueño de ser madres.
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How Does It Work?

The stem cell treatment for improving endometrial quality involves the application of 10 million stem cells directly into the uterine tissue. This innovative approach is designed to enhance pregnancy success rates in patients who have experienced recurrent implantation failures or repeated pregnancy losses associated with endometrial issues.

In cases such as Asherman’s Syndrome, which causes scarring within the uterus and compromises endometrial receptivity, or after surgical corrections that impact uterine quality, the application of stem cells can be an effective solution to restore endometrial health.
Stem cells have the unique ability to regenerate damaged tissues, promoting the growth of new healthy cells and improving the vascularization of the endometrium. This regeneration not only increases the thickness of the endometrial tissue but also enhances its receptivity to embryo implantation, significantly improving success rates in In Vitro Fertilization (IVF) and other Assisted Reproductive Techniques (ART).
For patients experiencing implantation failure—those who have undergone multiple unsuccessful IVF cycles due to endometrial receptivity issues—stem cell therapy provides a renewed opportunity to enhance the uterus's response to fertility treatments. These cells regenerate damaged uterine tissue, increasing the likelihood of proper embryo implantation and a successful, sustained pregnancy.
Additionally, in cases of recurrent pregnancy loss caused by low-quality endometrial tissue, stem cell treatment has proven effective in improving the structure and functionality of the endometrium. The application of stem cells strengthens the uterine lining, creating a more favorable environment for pregnancy development.
This treatment is also particularly beneficial for patients who have undergone uterine surgeries, as surgical interventions can leave scarring that hinders the endometrium's ability to support an embryo. By applying stem cells, damaged areas are repaired, restoring uterine functionality.
In summary, the application of 10 million stem cells into the endometrium is an innovative and effective solution for enhancing pregnancy probabilities in women with uterine receptivity issues. By regenerating and improving the quality of the endometrial tissue, this treatment offers new hope for patients who have faced challenges in conceiving due to implantation failures, recurrent losses, or prior surgeries. Through this therapeutic approach, fertility treatment success rates can be significantly increased, giving patients a greater chance of fulfilling their dream of becoming mothers.

You’re in the Best Hands!

Our research team is deeply committed to innovation and education in reproductive sciences, continuously striving to develop cutting-edge technologies that enhance fertility treatments. Our goal is to increase success rates and help our patients achieve their dream of having a baby as quickly as possible. Through advanced research and the development of new techniques like Endogen, we are revolutionizing Assisted Reproductive approaches to maximize outcomes in every treatment.
Endogen is one of the most innovative treatments we’ve developed in collaboration with esteemed researchers from Cinvestav-IPN. This partnership enables us to integrate state-of-the-art scientific advances into our treatments, placing us at the forefront of the fertility field. Endogen is a groundbreaking technique aimed at improving endometrial quality and optimizing uterine conditions to facilitate embryo implantation, significantly increasing success rates in In Vitro Fertilization (IVF) and other Assisted Reproductive Techniques.

Our research team’s focus extends beyond developing new technologies; it also includes training and preparing the next generation of specialists in reproduction. Our mission is to ensure that every scientific and technological advancement is effectively implemented in clinical practice, ensuring our patients receive the most up-to-date benefits from reproductive science.

Thanks to our collaboration with renowned research institutions like

Cinvestav-IPN, we continue to innovate and refine our treatments. This allows us to offer personalized and effective solutions to our patients, not only increasing success rates but also reducing the time needed to achieve a successful pregnancy. With these advancements, we ensure we remain at the cutting edge of science and reproductive medicine, providing our patients with the best opportunities to fulfill their dream of having a baby.

Bibliography

- Santamaria, Xavier et al. “Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study.” Human reproduction (Oxford, England) vol. 31,5 (2016): 1087-96. doi:10.1093/humrep/dew042

- Singh, Neeta et al. “Autologous stem cell transplantation in refractory Asherman's syndrome: A novel cell based therapy.” Journal of human reproductive sciences vol. 7,2 (2014): 93-8. doi:10.4103/0974-1208.138864

- Sudoma I et al. “Application of autologous

-adipose-derived stem cells for thin endometrium treatment in patients with failed ART programs.” J Stem

- Cell Ther Transplant. vol 3: (2019):001-008. DOI: 10.29328/journal.jsctt.1001013

-Nazari, Leila et al. “Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study.” International journal of reproductive biomedicine vol. 14,10 (2016): 625-628.

- Tandulwadkar, Sunita R et al. “Autologous Intrauterine Platelet-Rich Plasma Instillation for Suboptimal Endometrium in Frozen Embryo Transfer Cycles: A Pilot Study.” Journal of human reproductive sciences vol. 10,3 (2017): 208-212. doi:10.4103/jhrs.JHRS_28_17

-Sfakianoudis, Konstantinos et al. “Successful Implantation and Live Birth Following Autologous Platelet-rich Plasma Treatment for a Patient with Recurrent Implantation Failure and Chronic Endometritis.” In vivo (Athens, Greece) vol. 33,2 (2019): 515-521. doi:10.21873/invivo.11504

- Agarwal, Meenu et al. “Management of a Thin Endometrium by Hysteroscopic Instillation of Platelet-Rich Plasma Into The Endomyometrial Junction: A Pilot Study.” Journal of clinical medicine vol. 9,9 2795. 30 Aug. 2020, doi:10.3390/jcm9092795

- Aghajanzadeh, Fateme et al. “Using autologous intrauterine platelet-rich plasma to improve the reproductive outcomes of women with recurrent
implantation failure.” JBRA assisted reproduction vol. 24,1 30-33. 30 Jan. 2020, doi:10.5935/1518-0557.20190055

- Allahveisi, Azra et al. “The effect of platelet-rich plasma on the achievement of pregnancy during frozen embryo transfer in women with a history of failed implantation.” Heliyon vol. 6,3 e03577. 12 Mar. 2020, doi:10.1016/j.heliyon.2020.e03577

- Du, Juan et al. “Efficacy and safety of platelet-rich plasma for the treatment of thin endometrium: A protocol for systematic review and meta-analysis.” Medicine vol. 99,3 (2020): e18848. doi:10.1097/MD.0000000000018848

- Kusumi, Maki et al. “Intrauterine administration of platelet-rich plasma improves embryo implantation by increasing the endometrial thickness in women with repeated implantation failure: A single-arm self-controlled trial.” Reproductive medicine and biology vol. 19,4 350-356. 25 Jun. 2020, doi:10.1002/rmb2.12334

- Samy, A. et al. “Effect of autologous platelet-rich plasma transfusion in the treatment of infertile women with thin endometrium and its implications in IVF cycles: a literature review.” Middle East Fertility Society Journal vol. 25,5 (2020): 1-6. https://doi.org/10.1186/s43043-020-0019-5

- Tehraninejad, Ensieh S et al. “Autologous platelet-rich plasma infusion does not improve pregnancy outcomes in frozen embryo transfer cycles in women with history of repeated implantation failure without thin endometrium.” The journal of obstetrics and gynaecology research vol. 47,1 (2021): 147-151. doi:10.1111/jog.14445

- Zamaniyan, Marzieh et al. “Effect of platelet-rich plasma on pregnancy outcomes in infertile women with recurrent implantation failure: a randomized controlled trial.” Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology vol. 37,2 (2021): 141-145. doi:10.1080/09513590.2020.1756247

- de Miguel-Gómez, Lucía et al. “Comparison of different sources of platelet-rich plasma as treatment option for infertility-causing endometrial pathologies.” Fertility and sterility vol. 115,2 (2021): 490-500. doi:10.1016/j.fertnstert.2020.07.053

- Mouanness, Marco et al. “Use of Intra-uterine Injection of Platelet-rich Plasma (PRP) for Endometrial Receptivity and Thickness: a Literature Review of the Mechanisms of Action.” Reproductive sciences (Thousand Oaks, Calif.) vol. 28,6 (2021): 1659-1670. doi:10.1007/s43032-021-00579-2

- Jackman, Janelle M. et al. "Platelet rich plasma (PRP) can improve pregnancy outcome in patients with recur-rent implantation failure (RIF) and thin endometrial lining." Fertility and Sterility, vol. 114,3 (2020): e333, doi:10.1016/j.fertnstert.2020.08.901.
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