Endometrial Regeneration for Patients with Asherman’s Syndrome

Asherman’s Syndrome is a rare condition that profoundly impacts women’s reproductive health, causing infertility and difficulties in achieving a successful pregnancy. However, thanks to advancements in reproductive medicine, Ingenes has developed an innovative treatment called Endogen, which offers a safe, efficient, and accessible solution to regenerate the endometrium and restore fertility.

With significantly higher success rates and a less invasive approach, Endogen, with research led by Dr. Dinorah Hernández, represents the forefront of endometrial regeneration for patients with this condition. Discover how this technology can make a difference in your journey toward a successful pregnancy.

What is Asherman’s Syndrome?

Asherman’s Syndrome is an underdiagnosed condition considered a rare disease (orphan disease) caused by trauma to the endometrium. This damage creates intrauterine adhesions that result in an atrophic endometrium, unable to develop properly for embryo implantation and pregnancy.

It is characterized by the formation of scar tissue within the uterus, affecting its structure and functionality. This disorder can lead to secondary infertility due to recurrent miscarriages and difficulty maintaining a pregnancy.

How is it acquired?

Asherman’s Syndrome is an acquired condition, generally caused by:

• Uterine surgical procedures: Such as curettage, cesarean sections, myomectomies, or polyp removal.
• Severe uterine infections.
• Spontaneous or induced miscarriages.

Although it is not hereditary, recent research suggests a possible genetic predisposition in some women to develop intrauterine adhesions.

Causes and Symptoms

How to suspect someone has Asherman’s Syndrome?

Common symptoms include:

• Absence of menstruation (amenorrhea): Prolonged periods without menstrual bleeding.
• Very light menstrual flow (hypomenorrhea): Reduced or irregular menstrual bleeding.
• Severe pelvic pain: Associated with the retention of menstrual flow.
• Recurrent miscarriages or difficulty conceiving.

Additionally, the syndrome can occur suddenly after a miscarriage, uterine surgery, or infection.

Diagnosis and Standard Treatment

Diagnosis

Diagnosis requires advanced tools such as:

1. Sonohysterography: Using saline solution to observe the uterus's interior via ultrasound.
2. Hysteroscopy: Inserting a camera to directly visualize the adhesions.

Standard Treatment

As a rare disease, few treatment options exist. The primary goal of conventional treatment is only to remove scar tissue and restore the uterus's shape. This includes:

• Surgical hysteroscopy: Using specialized micro-surgical tools to remove adhesions.
• Complementary therapies: Intrauterine devices (IUDs) and hormonal treatments (estrogen) to prevent the recurrence of adhesions.

However, the endometrium often remains damaged, and many patients face recurrent adhesions. In severe cases, a thin endometrium (<5 mm) makes achieving pregnancy extremely difficult.

Endogen: Innovation from Ingenes

In cases where standard treatment is not enough, Ingenes offers Endogen, an innovative approach that regenerates endometrial tissue and restores its functionality.

How does Endogen work?

The uterus contains a natural niche of mesenchymal stem cells (EnMSC) that allow monthly regeneration of the endometrium. In Asherman’s Syndrome, this niche is destroyed, leaving the endometrium unable to respond to hormonal stimuli or sustain a pregnancy. Endogen replenishes these stem cells, regenerating endometrial tissue to achieve optimal thickness (>7 mm) and ideal functionality.

Advantages of Endogen Over Other Treatments

Unlike other experimental approaches requiring complex surgical procedures and extended stays abroad, Endogen is:

• Safer: Does not involve invasive surgeries or significant risks.
• More effective: Offers significantly higher pregnancy success rates.
• More accessible: Available locally at Ingenes, with personalized care and support from leading reproductive medicine experts.

Why choose Endogen at Ingenes?

1. Scientific innovation: With advancements led by Dinorah Hernández, the Ingenes team is at the forefront of reproductive research.
2. Proven results: Patient testimonials and preliminary data support its effectiveness.
3. Comprehensive support: In addition to medical treatment, patients receive emotional and psychological support throughout the process.

Conclusion

Asherman’s Syndrome no longer needs to be an insurmountable obstacle. With the development of Endogen, Ingenes leads innovation in reproductive medicine, offering an advanced, safe, and effective solution. This treatment regenerates the endometrium and significantly increases the chances of achieving a successful pregnancy.

If you are looking for a reliable and scientifically supported alternative to treat Asherman’s Syndrome, contact us today. At Ingenes, we are ready to support you in this process with cutting-edge technology and the expertise of professionals like biotechnologist and scientist Dinorah Hernández, who lead this revolution in reproductive health.